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Choroid plexus size linked to Alzheimer’s disease – Neuroscience News

summary: A new study suggests that increased choroid plexus size appears to be linked to greater cognitive impairment and Alzheimer’s disease.

source: RSNA

A new study published in the journal shows that increasing the size of an important brain structure called the choroid plexus is linked to greater cognitive impairment and Alzheimer’s disease. rays.

The choroid plexus is a network of blood vessels, connective tissue, and cells located in spaces of the brain called the ventricles. The plexus plays an important role in brain health. It is a gateway for immune cells from the blood to the brain. As a primary site for the production of cerebrospinal fluid, it is critical for the removal of waste and toxic proteins from brain cells.

This role is particularly important in the case of Alzheimer’s disease. Recent research indicates that disease progression is linked to the buildup of abnormal proteins called amyloid and tau and subsequent neurodegeneration.

said study author Won Jin Moon, MD, professor of radiology and chair of the department of radiology at Konkuk University College of Medicine in Seoul, Korea.

“Thus, we hypothesize that the abnormal state of the choroid plexus is associated with clearance failure resulting in the accumulation of waste and toxic proteins in the brain and failure of immune surveillance leading to neuroinflammation.”

Little is known about the choroid plexus imaging profile in cognitive impairment.

To find out more, Dr. Moon and colleagues performed MRI scans on 532 participants with various stages of cognitive impairment. Of the 532 participants, 132 underwent permeability imaging using contrast-enhanced dynamic MRI.

Choroid plexus size and permeability were associated with severity of cognitive impairment on brain MRI. The size of the choroid plexus was greater in people with Alzheimer’s dementia than in those without it. Higher choroid plexus volume was negatively correlated with memory. It also had negative effects on executive function, the broad set of mental skills that govern things like self-control and planning.

“Our study found that an enlarged choroid plexus volume is independently associated with increased cognitive impairment,” said Dr. Moon.

MRI processing steps. For volume measurement (left), choroid plexus (CP) volume (red) and cerebral cortex volume (green) are divided from T1-weighted volumetric images using an automated volumetric program (Inbrain) based on the FreeSurfer 6.0 platform (top row). White matter density (WMH) volumes (green) are also segmented from 3D (3D) or 2D (2D) Fluid Reflectance Attenuated (FLAIR) images using the same software (bottom row). Segmented mask sizes are binary. For the permeability and sensitivity plotting (right), the transmittance values ​​(volume transfer constant [Ktrans] and partial plasma volume) from contrast-enhanced dynamic MRI scans using the Patlake model, and CP transmittance values ​​are extracted using the co-registration of segmented CP (red) of T1-weighted images to the parametric map using the mutual information based algorithm (top row). The color scale bar represents the volume transfer constant (minimum 21). CP sensitivity scales are constructed in a similar manner. Quantitative sensitivity maps (QSM) are obtained from multi-dynamic images using QSMnet1 (lower row). Gray scale bar represents susceptibility to parts per million. Credit: Radiological Society of North America

“We did not find any relationship between choroid plexus size and amyloid pathology but there is a clear relationship between choroid plexus size and severity of cognitive impairment.”

The study results point to new possibilities for the role of magnetic resonance imaging in the diagnosis of Alzheimer’s disease.

“I think our findings on the choroid plexus could indicate that it’s a potential new alternative to MRI for a poor removal system and neuritis,” said Dr. Moon.

Other potential clinical applications include helping researchers develop new targeted drugs or therapies for filter failure and neuritis. Ultimately, choroid plexus measurements can help expedite treatment for those who need it most.

“If we combine choroid plexus volume and hippocampal volume in the screening phase, it may help us to better distinguish between the most vulnerable patients and the least debilitated patients,” said Dr. Moon.

The researchers plan to follow up with a longitudinal study. They will explore changes in the size of the choroid plexus over time as the disease progresses.

About this research on Alzheimer’s disease news

author: Linda Brooks
source: RSNA
Contact: Linda Brooks – RSNA
picture: The image is attributed to RSNA

original search: open access.
Choroid plexus volume and permeability in brain magnetic resonance imaging within the clinical spectrum of Alzheimer’s disease, by Jong Duck Choi et al. rays


a summary

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Choroid plexus volume and permeability in brain magnetic resonance imaging within the Alzheimer’s disease clinical spectrum

background

Increasing evidence suggests that the choroid plexus (CP) plays an important role in the pathophysiology of Alzheimer’s disease (AD), but its imaging profile in cognitive impairment remains unclear.

destination

To assess CP volume, permeability, and susceptibility using magnetic resonance imaging in patients at various stages of cognitive impairment.

Materials and methods

This retrospective study evaluated patients with cognitive symptoms who underwent 3.0-T MRI of the brain, including dynamic contrast-enhanced imaging (DCE) and quantitative sensitivity mapping (QSM), between January 2013 and May 2020. CP volume was automatically divided using three dimensionally weighted T1 sequences; volume transfer constant (ie Kvia) and the partial plasma volume (ie, Fifths) using DCE MRI, and sensitivity was assessed using QSM. The effects of CP volume, expressed as relative to intracranial volume, on cognition were assessed using multivariate linear regression adjusted for age, sex, education, E ε4 lipoprotein allele status and volumetric measurements.

consequences

A total of 532 patients had cognitive symptoms (mean age, 72 years ±9 .). [SD]; 388 women): 78 with subjective cognitive impairment (SCI), 158 with early mild cognitive impairment (MCI), 149 with late MCI, and 147 with AD. Of these, 132 patients underwent DCE and QSM. The volume of cerebral palsy was greater in patients in more severe stages (intracranial volume ratio × 10 .).3: 0.9 ± 0.3 for SCI, 1.0 ± 0.3 for early MCI, 1.1 ± 0.3 for late MCI, and 1.3 ± 0.4 for AD; s <.001). minimum Kvia (s = –0.19; s = .03) and Fifths (s = –0.20; s = .02) negatively with the magnitude of CP; were not allergic (s = 0.15; s = .10). CP volume was negatively correlated with memory (B = –0.67; standard error of the mean [SEM]0.21; s = .01 (Executive Function)B = –0.90; SEM, 0.31; s = .01), global perception (B = –0.82; SEM, 0.32; s = .01).

Conclusion

Among patients with cognitive symptoms, larger choroid plexus size was associated with cognitive impairment in the Alzheimer’s disease spectrum.

2022-05-17 21:38:45

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