High-fiber diets linked to lower antibiotic resistance in gut bacteria - Daily News Egypt

High-fiber diets linked to lower antibiotic resistance in gut bacteria – Daily News Egypt

Healthy adults who eat a varied diet containing at least 8-10 grams of soluble fiber daily have fewer antibiotic-resistant microbes in their guts, according to a study published by Agricultural Research Service scientists and colleagues at Mpio.

Microbes that have resistance to many commonly used antibiotics such as tetracyclines and aminoglycosides are a significant source of risk for people worldwide, with the widespread expectation that the problem of antimicrobial resistance (AMR) – the term for antibiotic-resistant bacteria, viruses and fungi – is due to likely to worsen in the coming decades.

Antimicrobial resistance in humans is highly dependent on their gut microbiome, as microbes are known to carry genetically encoded strategies to survive contact with antibiotics.

The findings lead directly to the idea that diet modification could be a new weapon in the fight against antimicrobial resistance. Nor are we talking about eating some exotic diets, but about a varied, fiber-appropriate diet that some Americans already eat,” explained research molecular biologist Danielle Lemay—study lead at ARS’s Western Human Nutrition Research Center in Davis, California.

In this study, the researchers were looking for specific associations of antibiotic resistance gene levels in human gut microbiota with animal fiber and protein in adult diets.

They found that regularly eating a diet with higher levels of fiber and lower levels of protein — particularly from beef and pork — was significantly associated with lower levels of antimicrobial resistance genes (ARG) among gut microbes.

Those with the lowest levels of ARG in their gut microbiome also had a greater abundance of strictly anaerobic microbes, bacteria that do not thrive in the presence of oxygen and are a hallmark of a healthy gut with reduced inflammation. Moreover, bacterial species in the family Clostridiaceae were the most common anaerobes found.

But the amount of animal protein in the diet was not a key indicator of high levels of ARG. The strongest evidence was that higher amounts of soluble fiber in the diet were associated with lower levels of ARGs.

“Surprisingly, the most important predictor of lower ARG levels – more so than fiber – was diet diversity. This suggests that we may want to eat from diverse sources of foods that tend to be higher in soluble fiber for maximum benefit.”

Soluble fiber, as its name suggests, dissolves in water and is the main type of fiber found in grains such as barley and oats. Legumes such as beans, lentils and peas. Seeds such as chia seeds and nuts. and some fruits and vegetables such as carrots, berries, artichokes, broccoli, and winter squash.

On the other end of the data, people with the highest levels of ARG in their gut microbiomes were found to have significantly less diversity of their gut microbiomes compared to groups with low and intermediate levels of ARG.

Our diets provide food for our gut microbes. All of this suggests that what we eat may be a solution to reducing antimicrobial resistance by modifying the gut microbiome,” LeMay said.

In all, 290 healthy adults participated in the study.

“But this is still just the beginning, because what we did was an observational study and not a study in which we introduced a specific diet to people who ate it, which would allow for more direct comparisons,” LeMay said.

“Ultimately, dietary interventions may be beneficial in reducing the burden of antimicrobial resistance and may ultimately stimulate dietary guidelines that will consider how nutrition can reduce the risk of antibiotic-resistant infections.”





2022-05-11 18:12:53

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