Patient 4, a man who was treated for monkeypox in London in 2019, appears to have made a full recovery from the virus but had a relapse after having sex six weeks after being given the full treatment, testing positive for the virus 70 days after onset.  He gets sick.  This chart tracks monkeypox PCR results using blood (red), throat swabs (green), urine (yellow), and lesions (black) over time.  It also shows how long he's had the initial monkeypox rash (dotted line)

A former patient in the UK had monkeypox in the body for 76 days

Scientists say the monkeypox virus may remain in the body for up to 10 weeks – even after the rash is gone.

Experts don’t believe patients can be contagious for this period of time, but say this remains the “big unanswered question”.

The results are from an analysis of the previous seven cases in the UK, which were dropped between 2018 and 2021.

Experts have been pushing to reassure parents that cases of children are extremely rare and any new rash in children is more likely to develop chickenpox or hand, foot and mouth disease.

Seventy-one Britons have so far contracted monkeypox, in an outbreak that has raised alarm around the world. There are a disproportionate number of cases in gay and bisexual men

Usually seen only in Africa, sporadic cases of tropical virus do appear in Britain, but outbreaks tend to subside naturally.

The new study also revealed that smallpox antivirals can help people fight the disease.

Tecovirimat, which is not officially approved to treat monkeypox, helped a patient infected in 2021 recover and be discharged from hospital after just a week of treatment.

The research revealed that one of seven previous cases in the UK – a man in his 40s who contracted monkeypox in Nigeria before being taken to hospital – was still positive 76 days after he first fell ill.

In what may be a world first if proven true, doctors believe he suffered a relapse after sex.

Patient 4, a man who was treated for monkeypox in London in 2019, appears to have made a full recovery from the virus but had a relapse after having sex six weeks after being given the full treatment, testing positive for the virus 70 days after onset. He gets sick. This chart tracks monkeypox PCR results using blood (red), throat swabs (green), urine (yellow), and lesions (black) over time. It also shows how long he’s had the initial monkeypox rash (dotted line)

The scientists also released details about patient 7, who was given tecovirimat in an effort to help her recover faster.  It was found that she recovered much faster than other patients, and crossovers on the graph indicate when she started her daily work from tecovirimat

The scientists also released details about patient 7, who was given tecovirimat in an effort to help her recover faster. It was found that she recovered much faster than other patients, and crossovers on the graph indicate when she started her daily work from tecovirimat

Experts say cases of monkeypox are rare in children and parents should not worry

Experts said parents should not worry about their children getting monkeypox, as cases in young children are rare, and any rash is likely to be due to chickenpox or foot, foot and mouth disease.

The reassurance comes as 71 confirmed cases of monkeypox have been reported in the UK.

Researchers who have conducted research into the current outbreak, as well as previous cases of the disease, say it’s rare in children.

Dr David Porter, Consultant Pediatric Infectious Diseases, Alder Hey Children NHS Foundation Trust, said: ‘As a parent with a child who may develop a rash, I don’t think parents should be concerned about this…monkey pox at this point, because we are seeing quite a few. Very many cases.

And in all of the previous outbreaks outside of Africa over the past few years, we’ve seen very rare numbers of cases in children, so they’ve been mostly among adults anyway.

And without any history of contact with someone who is known or feels strongly to have monkeypox, then if you’ve had a rash at this time of year when we’ve seen a lot of rashes from chickenpox and other things in children, hand, foot and mouth disease, that’s what probably be.

He added that if children have a rash and there is no history of contact with someone with monkeypox, parents and caregivers should be reassured and follow what they normally do.

The man, who has not been identified, had it all and was sent home from the hospital a few weeks after contracting the virus.

Six weeks later, when he had sex for the first time after getting sick, his virus returned.

Writing in the Lancet Infectious Diseases journal, the researchers told doctors how lymph nodes had enlarged in size.

This swelling came with the characteristic pustular skin lesions of monkeypox.

Subsequent polymerase chain reaction (PCR) tests for the lesions came back positive for the virus.

But the man’s relapse was brief and he was “otherwise clinically sound”.

Study author Dr Hugh Adler, from Liverpool’s College of Tropical Medicine, said they were “surprised” that monkeypox could be detected in the throat and blood for such an extended period of time.

“It remains positive in the throat and blood throughout the illness and possibly longer after the rash,” he said.

Traditionally, monkeypox patients are considered contagious while they have the characteristic rash and lesions.

But these tend to scab and fall off after a few weeks.

The man developed a second rash, which likely means that he has been infected again.

But while the man was the most extreme example, other patients tested positive for monkeypox on polymerase chain reaction (PCR) tests for up to four weeks after the rash had disappeared.

No other patients experienced a relapse.

Dr. Adler cautioned that more research is needed to confirm whether the virus can be transmitted after the characteristic rash has disappeared.

“We see no indication in our paper that these patients are contagious for longer than the rash persists,” he said.

“But it is a very remarkable discovery that has not been demonstrated before and is changing our understanding of how disease works.”

Dr Simon Clark, an infectious disease expert at the University of Reading who was not involved in the study, told MailOnline that the research highlighted how little we know about monkeypox.

“This suggests that the virus can persist for much longer than we realize in people,” he said.

Pictures, taken from patients treated in Britain for monkeypox, show the various lesions that can appear.  Picture H shows a deep subcutaneous cat abscess in one patient

Pictures, taken from patients treated in Britain for monkeypox, show the various lesions that can appear. Picture H shows a deep subcutaneous cat abscess in one patient

Dr Hugh Adler, author of the new study, said they

Dr Hugh Adler, author of the new study, said they were “surprised” that monkeypox could be detected in PCR tests, and if people could be contagious for longer than expected, that’s a “big unanswered question.”

Pets could keep spreading monkeypox across Europe forever: Health chiefs warn ferociously of triple UK cases in just three days

Health officials warned yesterday that monkeypox could spread to pets and wildlife and become an epidemic in Europe.

Experts on the continent sounded the alarm as it was announced that cases in the UK had nearly tripled in three days.

Another 37 cases have been confirmed in addition to the 20 already identified, bringing the total number to 57.

As of yesterday, there were 67 confirmed cases of monkeypox in nine European countries, including Spain, Italy, Germany, Sweden and France, and at least 42 suspected cases.

A rapid risk assessment published by the European Center for Disease Prevention and Control (ECDC) said that pet rodents, such as rats and mice, should ideally be isolated in ‘controlled facilities’ if they come into close contact with infected people.

In Africa, where monkeypox is endemic or well-established, the virus is often circulating in rodents including squirrels and flowers.

The European Center for Disease Control and Prevention said rodents and squirrels could be an ‘appropriate host’ and ‘extending event’, in which the virus spreads from humans to pets to wildlife, could lead to the spread of monkeypox in Europe.

“That doesn’t mean it’s like that in every case, it might just be a minority, but it’s an obvious possibility.”

He added that the idea that sex would cause a relapse in monkeypox was possible, but more studies were needed.

“It is not very difficult to imagine that a potential reservoir of this virus in the groin area could mean that the mechanisms of sexual activity could somehow, and we don’t know how, lead to a reactivation of the dormant virus,” he said.

As the authors say, this has been suggested for other infections, but it requires a lot of research.

In the main arm of the study, the researchers also revealed that tecovirimat could help patients recover faster.

Three patients were given brinkedofovir, while one received ticofermate.

Brincidofovir had no “convincing clinical benefit in the treatment of monkeypox”.

But the only patient treated with tecovirimat in 2021 experienced a ‘shorter duration of symptoms’, having been ill for about a week.

However, the scientists said that only one patient given the drug’s interpretation of the results is limited.

Tecovirimat was approved as a treatment for monkeypox in the European Union in January, but UK health drug regulators have not approved its use in general.

However, doctors can give it to patients “off-label”.

The authors acknowledge their sample size is too small but say the results should prompt further research into treating monkeypox patients with antivirals.

In the end, all patients treated in the UK made a full recovery.

The research came at just the right time, as the UK and several European countries are dealing with a growing outbreak of monkeypox.

British officials use the pokes to vaccinate contacts of confirmed cases, to form a barrier of immunity to limit the spread of disease.

The government has also urged high-risk contacts of monkeypox in the UK to self-isolate for three weeks as cases of infection rise across Britain.

All cases of monkeypox to date have been mild, and no deaths have been reported.

The virus usually causes fever, chills, rash, and lesions on the face or genitals. Most people recover within several weeks without requiring hospital treatment.

2022-05-24 22:30:46

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