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Coffee consumption may reduce risk of acute kidney injury: study

Maryland: A recent study by Johns Hopkins Medicine researchers suggests that coffee consumption is associated with a reduced risk of acute kidney injury (AKI).

The results, published May 5 in the journal Kidney International Reports, showed that those who drank any amount of coffee each day had a 15% lower risk of developing cardiovascular disease, with the largest reduction observed in the group who drank two to three cups a day. (22%-23% lower risk).

“We already know that drinking coffee on a regular basis has been associated with the prevention of chronic and degenerative diseases including type 2 diabetes, cardiovascular disease and liver disease,” says study corresponding author Chirag Parikh, MD, PhD, director of the Division of Pathology. Kidney and Professor of Medicine at Johns Hopkins University School of Medicine. “We can now add a potentially reduced risk of acute kidney failure to the growing list of health benefits of caffeine.”

AKI, as described by the National Kidney Foundation, is “a sudden episode of kidney failure or kidney damage that occurs within a few hours or a few days.” This causes waste products to build up in the blood, making it difficult for the kidneys to maintain the correct balance of fluids in the body.

Symptoms of acute renal failure vary depending on the cause and may include: little urine leaving the body; Swelling in the legs, ankles and around the eyes. fatigue; Shortness of breath; confusion; nausea; Source; In severe cases, seizures or coma. This disorder appears more commonly in hospitalized patients whose kidneys are affected by stress and medical and surgical complications.

Using data from the Atherosclerosis Risk in Communities Study, an ongoing survey of cardiovascular disease in four US communities, researchers evaluated 14,207 adults recruited between 1987 and 1989 with an average age of 54. Participants were surveyed seven times over 24 years. For the number of 8-ounce cups of coffee they consumed each day: zero, one, two to three, or more than three. During the survey period, 1694 cases of acute kidney injury were recorded.

When accounting for demographics, socioeconomic status, lifestyle influences, and dietary factors, there was a 15% reduction in AKI risk for participants who consumed any amount of coffee versus those who did not. When adjusting for additional comorbidities—such as blood pressure, body mass index (BMI), diabetes status, use of antihypertensive medications and kidney function—individuals who drank coffee still had an 11% lower risk of developing acute renal failure compared to those who did not. that.

“We suspect that the reason for coffee’s effect on the risk of acute renal insufficiency may be either that the bioactive compounds combined with caffeine or the caffeine itself improve perfusion and oxygen use within the kidneys,” Barrick says. “Good kidney function and tolerance of acute renal insufficiency – dependent on consistent blood and oxygen supply.”

Barrick says more studies are needed to determine the potential protective mechanisms of coffee consumption for the kidneys, especially at the cellular level.

“It has been hypothesized that caffeine inhibits the production of molecules that cause chemical imbalances and the use of too much oxygen in the kidneys,” he explains. “Maybe caffeine helps the kidneys maintain a more stable system.”

Barrick and colleagues note that coffee additives such as milk, half-and-half, cream, sugar, or sweeteners can also affect the risk of acute kidney failure and need further investigation. Additionally, the authors say that consumption of other types of caffeinated beverages, such as tea or soda, should be considered as a potential confounding factor.

Other researchers involved in this study include Emily Ho, Elizabeth Selvin and Joseph Koresh of the Johns Hopkins Bloomberg School of Public Health. Morgan Grams of Johns Hopkins University School of Medicine; Casey Rebholz of the Johns Hopkins School of Medicine and Bloomberg of Public Health Kalie Tommerdahl and Peter Bjornstad of the University of Colorado Anschutz Medical Center and Lyn Steffen of the University of Minnesota School of Public Health.

2022-06-03 14:47:00

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