Researchers create profile of COVID-19 deceased based on analysis of 140 complete autopsies

Researchers create profile of COVID-19 deceased based on analysis of 140 complete autopsies

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Men aged 60 to 77 with diffuse alveolar damage (DAD) – acute lung injury – in the reproductive stage. This is the most common profile of the deceased from COVID-19, as determined by researchers of the Department of Forensic Medicine and Forensic Medicine at the University of Malaga after analyzing 140 cases of complete autopsy.

Moreover, UMA scientists have demonstrated that these patients usually exhibit comorbidities such as vascular disease, heart disease and diabetes, and note that the deceased with this pattern died significantly in a shorter period of time.

“It is the first time that injuries found at autopsy and comorbidities presented by the patient — cases other than the underlying disease — have been associated with a faster likelihood of death,” says Jaime Martin, a medical school scientist. One of the authors of this paper, the results of which were published in the journal Current medical opinions and research.

Likewise, this team of Forensic Toxicology, Toxicology and Dental Group scientists, who are also members of IBIMA-Plataforma BIONAND, reveals that, after the lung, the kidneys are the second most affected organ, showing injuries such as blood clots and tubular damage.

New strategies to reduce mortality

The researchers note the important role of autopsies and their findings to determine the cause of death, as they allow knowledge of physiology, as well as to develop effective treatment strategies that reduce mortality.

“It should be an essential component of understanding any disease, but especially in newly emerging diseases like COVID-19,” they say. However, they cautioned that autopsies of those who died from the coronavirus are not being conducted in depth and not sufficiently studied.

systematic review

In order to conduct this research, the scientists performed a systematic review of the complete autopsy cases of death from COVID-19 found in the literature, excluding incomplete studies, duplicate cases, or autopsies with incidental diagnosis of COVID-19, among other aspects. The primary search strategy retrieved 1282 cases, of which 140 were finally analyzed (92 men and 48 women).

The new goal of this research team is to address the consequences of SARS-CoV-2 infection in different organs, for example, the kidneys or the heart, based on a greater number of autopsies that include microscopic and microscopic findings. Its members include Stella Martin, Leticia Rubio, Fernando Martin and Juan Suarez.

COVID-19 as a systemic disease: what does it mean for the kidneys?

more information:
Jaime Martin Martin et al., Comorbidities and autopsy findings for COVID-19 deaths and their association with time to death: a systematic review and meta-analysis, Current medical opinions and research (2022). doi: 10.1080/03007995.2022.2050110

Presented by the University of Malaga

the quote: Researchers create profile of COVID-19 deceased based on analysis of 140 complete autopsy cases (2022, June 3) retrieved June 3, 2022 from analysis on the deceased. html

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2022-06-03 15:56:03

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