Epidemic diabetes care disorder associated with higher mortality risk

Sexual dysfunction is common in individuals with prediabetes and type 2 diabetes

MidwireMen and women with prediabetes or type 2 diabetes have high levels of impotence, shows an analysis of data from the US Diabetes Prevention Program (DPPOS) Outcomes Study.

Metabolic factors appear to influence the risk of sexual dysfunction in men in this group, while in women important risk factors appear to be non-metabolic.

The Diabetes Prevention Program (DPP) was a well-known study developed by the University of Pittsburgh that was conducted between 1996 and 2001 to compare treatment with metformin, an intensive lifestyle intervention, or a placebo in 3,234 adults with prediabetes. After the lifestyle intervention was successful, the study was stopped and all participants were offered the lifestyle intervention. DPPOS followed DPP participants from 2002 to the present to study long-term outcomes.

The DPPOS paper was presented by Yooni Blair (University of Michigan, Ann Arbor, USA) as abstracts at the 82nd Scientific and ADA sessions in New Orleans, Louisiana.

Commenting on the study’s rationale, Blair told delegates: “Previous studies have found an association between erectile dysfunction (ED) and type 2 diabetes. It occurs more commonly, and often earlier. […]. However, there is a lack of data for men with prediabetes as well as risk data for people with type 2 diabetes.”

She added, “The prevalence of diabetes worldwide is staggering, but male impotence is also expected to reach hundreds of millions worldwide. This underlines the importance of understanding the relationship between these two entities.”

For the purposes of this study, measures were taken from the 15-year DPPOS cohort in 2017. At this point, 568 of 648 male participants completed the International Index of Erectile Function (IIEF), while 426 of 1464 female participants, all of whom were sexually active, completed the The female sexual function index (FSFI).

The researchers found that 218 men in the group had ED — 41% of men with prediabetes and 37% of those who had type 2 diabetes. Men with erectile dysfunction tended to be older, of white race, weigh more, and were more likely to have depression, high blood pressure and high cholesterol than those without ED.

Blair explained that in multivariate analyses, men with type 2 diabetes and metabolic syndrome were 72% more likely to develop erectile dysfunction compared to patients with diabetes alone, while exposure to a lifestyle intervention appeared to significantly reduce the risk of ED in men with diabetes. prediabetes by 74%.

Female sexual dysfunction (FSD)—scored across six domains, including desire, arousal, lubrication, orgasm, satisfaction, and pain—was common in women with prediabetes or type 2 diabetes (43.4% overall) . These women were more likely to be older, married, depressed, heavier, postmenopausal, post-hysterectomy, and incontinent than those without FSD.

But, unlike what was found in men, the research showed that FSD was more related to non-metabolic factors. Depression, incontinence, and Asian ethnicity were all significantly associated with FSD in this group of women with ORs of 2.81, 2.14, and 5.06, respectively.

“This suggests that women’s sexual response may be influenced more by psychosocial aspects rather than metabolic control or complications of diabetes,” Blair commented.

medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2022 Springer Healthcare Ltd, part of the Springer Nature Group

ADA Scientific Sessions; New Orleans, Louisiana: June 3-7, 2022 (86-OR summary)
ADA Scientific Sessions; New Orleans, Louisiana: June 3-7, 2022 (Summary 87-or

2022-06-06 17:17:43

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