Strong T-cell response in leukemia patients after vaccination;  COVID hack is often dangerous for cancer patients

Strong T-cell response in leukemia patients after vaccination; COVID hack is often dangerous for cancer patients

Written by Nancy Lapid

Below is a summary of some recent studies on Corona virus disease19 and cancer presented at the annual meeting of the American Society of Clinical Oncology (Asco) in Chicago.

Leukemia patients show a strong T-cell response Corona virus disease Vaccines

Patients with leukemias have a much weaker antibody response Corona virus diseaseNew data suggest that -19 vaccines compared to patients with solid tumors, but may still be well protected from becoming seriously ill from the virus.

Researchers at Monash University in Australia studied immune responses after three doses of Corona virus disease Vaccines from Moderna, Pfizer/BioNTech, or AstraZeneca in nearly 400 adults with active or recently treated cancers. Only 3.2% of 256 patients with solid tumors lacked neutralizing antibodies SARSToday, Saturday, researchers reported that -CoV-2 and infection prevention, compared to 30% of 137 people with malignant blood tumors. Asco 2022. But the responses of immune cells called T cells, some of which can kill virus-infected cells, were similar regardless of the type of cancer. The T-cell responses may thus indicate immune protection “for those without an antibody response,” the researchers said.

The same team reported in a separate presentation on Saturday that the data on the safety of Corona virus disease19 vaccines for cancer patients are “reassuring”. Survey responses of nearly 500 adults and children showed that most experienced some after-effects, with injection site pain and fatigue being the most common. But severe reaction rates were low (range 0%-10%) and interruptions in cancer treatment were uncommon (0%-11%). “No significant change in quality of life was reported for dose 1 or 2, in children or adults,” the researchers said.

breakthrough Corona virus disease19 in cancer patients is often dangerous

A large proportion of vaccinated cancer patients develop a mutation Corona virus disease-19 require hospitalization, according to data collected by the American Society of Clinical Oncology and reported in Asco 2022.

Researchers studied 231 patients who developed superinfections while receiving cancer treatment or within a year of treatment. Patients received at least one dose of the vaccine from Pfizer/BioNTech, Moderna, or Johnson & Johnson. Most breakouts occurred after more than six months. Among the patients with solid non-metastatic tumors and penetrating infections, approximately 20% were hospitalized. Hospitalization rates for leukemia patients with breakthrough Corona virus disease-19 ranged between 32% and 56%.

“While the proportion of patients in Asco The record with hospitalized breakthroughs remained fairly constant throughout 2021 (about 40%), and the hospitalization rate was lower than for those with breakthroughs that occurred in the last month of 2021 and early 2022 (about 20%), This corresponds to less severe cases Corona virus disease-19 in patients with the Omicron variant,” the researchers said in their presentation summary SARSThey said that MERS-2 infection that occurs six months or more after vaccination indicates a decline in vaccine efficacy over time, which could be affected by additional doses.

Cancer patients too much for a long time Corona virus disease Collection

Cancer patients represent a large proportion of the people who end up with bothersome and persistent symptoms after recovery Corona virus disease-19, a case known as length Corona virus diseaseUS researchers reported Saturday in Asco 2022.

From a nationwide representative sample of more than 4.3 million people diagnosed with Corona virus disease-19 Between January 2020 and February 2022, they identified 1,700 tall adults Corona virus disease It found that 37.3% were patients with cancer. The most common cancers were skin (21.9% of cancer patients), breast (17.7%), prostate (8.3%), lymphoma (8%) and leukemia (5.7%).

between long Corona virus disease Patients, those with cancer were older than those without cancer, more likely to have other medical conditions, and more likely to be hospitalized because of Corona virus disease-19. The researchers called for “further investigation to identify risk factors for a prolonged period of time.” Corona virus disease in cancer patients.

Click for a Reuters graphic https://tmsnrt.rs/3c7R3Bl on vaccines in development.

2022-06-06 19:28:50

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