Symptoms last up to two years for some.  Inflammatory protein patterns may provide lingering clues about COVID

Symptoms last up to two years for some. Inflammatory protein patterns may provide lingering clues about COVID

Written by Nancy Lapid

Below is a summary of some recent studies on Corona virus disease-19. They include research that requires further study to confirm results and that has not yet been approved by peer review.

Corona virus disease19 symptoms still appear after 2 years

Half Corona virus diseaseA new study shows that 19 patients discharged from a Chinese hospital in early 2020 still had at least one symptom two years later.

Overall, regardless of initial disease severity, 2,469 Corona virus disease– 19 survivors in the study improved in physical and mental health over time. Nearly 90% of those hired have returned to their jobs within two years. But survivors had “significantly” lower health status than the general population at two years, and their symptom burden from after-effects remained “fairly high,” the researchers reported Wednesday in The Lancet Respiratory Diseases. Within two years, 55% still had at least one Corona virus disease19 after the impact according to the report. Fatigue or muscle weakness was the most frequently reported symptom during the study. Patients who required mechanical ventilation for critical illness continued to have high rates of lung impairment within two years.

“Our findings suggest that a certain proportion of hospitalization is treated.” Corona virus disease-19 survivors, while they have cleared the initial infection, need more than two years to fully recover from the disease Corona virus diseaseThe researchers said.

Protein ‘patterns’ may aid in long-term classification Corona virus disease The patients

Inflammatory patterns in people’s blood with long patterns Corona virus disease They may one day help guide individual treatment, new findings suggest.

Researchers studied 55 people with long Corona virus disease who had only mild disease Corona virus disease19 and found that nearly two-thirds of them had high levels of inflammatory proteins in their blood, with persistent inflammation likely to be present in individuals with the highest long-term burden. Corona virus disease symptoms. While previous research has shown high levels of these proteins for a long time Corona virus disease Patients, we provide the first evidence that more than half “have a specific signature or pattern, while others do not,” researchers reported Tuesday on bioRxiv ahead of a peer review.

“At least two different patterns of inflammatory proteins have been detected,” said study leader Troy Torgerson of the Allen Institute for Immunology in Seattle. The presence of these patterns suggests that the immune system is activated in specific ways that can respond to treatment with current anti-inflammatory or immunosuppressive drugs, Torgerson said. Measuring these proteins in the blood can help to identify for a long time Corona virus disease Patients who may be good candidates for studies of treatment with these drugs or for potential future therapies.”

Mixing vaccines can make vaccines appear less effective

Increasing contact between vaccinated people can give a false impression of this Corona virus disease– 19 vaccines do not work .. Researchers warn.

Some studies have indicated that vaccinated people are infected at higher rates than unvaccinated individuals, but these studies likely include statistical errors, especially if they don’t take into account the different communication patterns between vaccinated versus unvaccinated people, said Corryn Bodner. from St. Hospital, Unity Health Toronto. Using computer models to simulate epidemics with a vaccine that protects against infection and its transmission, her team identified conditions that could create a “perfect storm for monitoring negative vaccine efficacy even when the vaccine is effective,” Bodner said. Effective vaccines may appear ineffective when vaccinated people have more contact with each other than unvaccinated people, when vaccine benefits are reduced but not absent (as has been the case with novelties) SARS-CoV-2), or when measuring efficacy during the growth of an epidemic (such as the emergence of a new variant), according to a report published on medRxiv prior to peer review.

Simulations do not demonstrate that this type of bias influenced studies of the efficacy of the vaccine versus the Omicron variant. However, they showed that “even if vaccines work, increased contact between vaccinated people can result in the vaccine not working,” Bodner said.

Click for a Reuters graphic of vaccines in development.

2022-05-12 20:43:01

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