Eating extracts of this ugly sea creature may reverse aging - study in mice

Eating extracts of this ugly sea creature may reverse aging – study in mice

mice feed with A recent study out of China showed that extracts from a creature called sea spray – so named because it tends to splash water when plucked from its salty house – reversed some signs of aging.

Extracts fed to mice are called plasmalogens – a type of lipid (lipid) found in the membranes of cells in human organs such as the brain, kidneys, muscles and lungs. They have a variety of functions, including regulating how cells exchange information, protecting cells from DNA damage, and reducing inflammation.

Previous research has shown that the amount of plasmagens in the blood decreases with age, especially in people with Alzheimer’s disease, the most common form of dementia.

Plasmalogens . explained

Significant amounts of plasmogens are found in foods such as chicken, pork, beef, mussels, scallops and of course sea bream that are eaten in Korea and Japan.

In this latest study, researchers gave plasmogens to middle-aged females at much higher concentrations (about 300 to 500 times higher) than would normally be found in a portion of chicken or scallops for example. Then they assessed the mice’s memory and some important factors that change in the brain with age.

This included the number of neural stem cells, which generate new nerve cells (brain cells), and the number of connections between neurons. Both are important for maintaining the ability to learn, remember and reason.

They found that all of these parameters improved when the mice were fed plasmagens for two months. Also, inflammation was significantly reduced in the mice fed the plasmagenes compared to those on a typical diet (the control group). Inflammation increases with age and is thought to be an important cause of worsening symptoms of Alzheimer’s disease.

The researchers also showed that the mice improved memory. To do this, they used a test – called the Morris water maze – that uses sensory skills, including good eyesight, to learn to perform a task.

How does the Morris water maze task work?

Unfortunately, mice tend to lose sensory skills such as blindness and hearing with age, and so these findings should be treated with caution. The marked improvement in memory could be the result of improved sensory skills, not memory.

However, these latter findings are supported by a previous study in which subjects with mild cognitive impairment were fed plasmagenes (this time from scallops) twice daily for 24 weeks. The participants given the plasmogens showed an improved memory. However, this improvement was only observed in a subgroup of patients younger than 77 years of age. The reason for its success with only this subgroup is unclear and needs further study with a larger group of participants.

Anti-aging devices: drugs that delay cell aging

Although these findings are intriguing, more work is needed to find out whether plasmalogens are really “geroprotectors” – drugs that delay cell aging, and thus reduce the risk of many age-related diseases. It is important to know how plasmagens delay aging and whether their effects extend beyond the brain to other important organs, such as the heart, muscles, and immune system.

More than 200 bacteriostatic devices have been tested in animals. In several studies, researchers have shown that geroprotectors can improve the function of vital organs. A handful of these agents have also been shown to delay the onset and severity of chronic age-related conditions such as osteoporosis, heart disease, osteoporosis, and Alzheimer’s disease in laboratory animals.

The next step is to test these drugs in people, but this is difficult because of the way the drugs are tested and approved for use. This usually occurs in people with a specific disease and once the disease has been diagnosed. However, these drugs are likely to give the best results when taken to ward off age-related diseases.

They may even prevent more than one disease at the same time. To test it, researchers need to identify people at risk for one or more age-related diseases, then run a long and expensive trial to see who gets the disease and who is protected.

To reduce testing time, researchers are now developing ways to predetermine who will develop certain age-related diseases. But even if these studies are successful, the question remains whether the use of anti-aging tools to prevent disease is cost-effective and safe. Other measures, such as an improved diet and exercise, are probably just as good, if not better.

This article was originally published Conversation Written by Ilaria Bellantono at the University of Sheffield. Read the original article here.

2022-06-06 12:00:28

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