New Study Published in Clinical Cell Reports Further Checks Potential of Urolithin A Supplementation in Supporting Muscle Health – Benzinga

  • A randomized, double-blind, placebo-controlled trial found that Mitopure™ Urolithin A improves muscle strength and exercise performance. In middle-aged adults

Bridgewater, New JerseyAnd May 17 2022 /PRNewswire/ — Nestlé Health Science, the global leader in nutritional sciences, has announced the results of the Atlas trial have been published in Medicine Cell Reports. Data show improvement in leg muscle strength in those who took Mitopure supplement daily for four months. Mitopure, a proprietary form of Urolithin A produced by Amazentis, works by supporting cells’ ability to regenerate their own power plants, the mitochondria. The decline in mitochondrial function occurs during aging and is associated with decreased physical performance such as slower walking speed, muscle fatigue, and loss of strength. Using nutritional supplements to support mitochondrial health is a new approach to help address age-related decline in muscle and cellular health.

“It is very promising that we have more robust clinical data to support the benefit of Mitopure supplementation on muscle health and exercise performance as we age,” he said. Anurag Singh, chief medical officer of Amazonis and co-author of the study. “Until recently, interventions to counteract age-related muscle decline have been limited. Exercise and dietary approaches such as increasing protein intake are the most studied ways to help mitigate such declines, but we know that people do not always adhere to such regimens. What is particularly important is We see Mitopure improve physical performance outcomes in the absence of an exercise regimen. These studies highlight the potential of Mitopure supplementation as a new nutritional solution to help maintain muscle function in middle-aged adults.”

As people age, a gradual decline in muscle mass and strength is normal, and environmental factors such as diet and exercise can affect the rate at which these declines occur. Stimulating mitophagy, removing and recycling dysfunctional mitochondria to enhance mitochondrial synthesis, can help improve mitochondrial function and promote overall cellular health. Previous research shows that Mitopore — which is molecularly identical to a natural gut metabolite derived from the microbiome produced from foods such as pomegranate, nuts and berries — activates mitophagy.

The ATLAS trial was a randomized, double-blind, placebo-controlled study that examined the effect of daily supplementation with Mitopure (500 mg or 1000 mg) or placebo for 4 months on muscle performance in 88 stable adults aged 40-64 years. The trial end points included muscle strength, exercise endurance, and physical performance. The results are an important finding in muscle health research and are as follows:

  • Improvements in hamstring muscle strength were significantly greater among participants who took Mitopure daily at 500 mg (12% increase vs. baseline) or 1,000 mg (10% increase vs. baseline) compared to placebo. This is key, because maintaining muscle tone is important for healthy aging.
  • Individuals consuming 1,000 mg of Mitopure daily experienced clinically meaningful improvements in aerobic endurance (10% increase in peak oxygen consumption). [VO2]), and physical performance (33 m improvement in 6-min walking test), from baseline to 4 months.
  • Mitopure supplementation has enhanced cellular health as it relates to mitochondrial efficiency and reduced inflammatory markers, both of which are important for optimal muscle function.
  • Mitopure supplements have also been found to be safe and well tolerated.

Furthermore, the ATLAS results are based on data from recent trials examining the benefits of Mitopure supplementation. A randomized, crossover trial demonstrated improved bioavailability of Mitopure compared to food sources of Urolithin A, since two-thirds of individuals do not have the appropriate microbiome to make UA from their diet alone. A randomized controlled trial of adults aged 65-90 years found that daily supplementation of 1,000 mg of Mitopure significantly improved hand and leg muscle endurance at two months. Taken together, these studies show that Mitopure can positively impact muscle and cellular health in middle-aged and older adults, which is impressive given that the age-related decline in muscle mass and strength can begin as early as 40 years of age.

“We want to empower people to take control of how they age, and we continue to see the positive impact that Mitopure supplementation can have on muscle function and cellular health,” Rick Giants, Head of the Global Category for Cellular Nutrition at Nestlé Health Science. “Celltrient Cellular Strength, which contains this special form of Urolithin A, provides an accessible solution to help support muscle health as you age. Our goal is to continue to rewrite the course of aging by providing scientifically studied cellular nutrition options like Urolithin A.”

The full study is registered with as: NCT03464500.

urolithin A

Urolithin A (UA) is a cellular nutrient that activates mitochondrial regeneration to support efficient mitochondrial function, which is important for muscle strength and endurance. UA is formed by gut bacteria when foods containing ellagitannins, a beneficial plant compound, are consumed. However, about two-thirds of adults are unable to produce UA in this way, which is why supplementation may be beneficial.

Celltrient™ Nutrition

Nestlé Health Science introduced Celltrient™ Cellular Nutrition, a specialized range of nutritional solutions designed to support cellular health. Celltrient offers Cellular Strength Mitopure™, a proprietary form of UA. For more information on Celltrient Cellular Nutrition, visit

About Nestlé Health Science (NHSc)

Nestlé Health Science is a leading nutritional sciences company and a globally managed business unit of the Nestlé Company. We believe in enabling healthier lives through nutrition and are committed to redefining health management, offering a broad spectrum of science-based active nutrition, medical nutrition and pharmaceutical solutions. Our extensive research network, within Nestlé’s R&D centers as well as with external partners, provides the foundation for products that can help people live healthy lives. Headquartered in Switzerland, we have more than 11,000 employees worldwide, with products available in more than 140 countries.

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Source: Nestle Health Science

2022-05-17 20:40:00

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