Discovery reveals that blocking inflammation can lead to chronic pain

Using anti-inflammatory drugs and steroids to relieve pain can increase the chances of developing chronic pain, researchers from McGill University and colleagues in Italy said. Their research raises questions about the traditional practices used to relieve pain. Normal recovery from a traumatic injury includes inflammation, and preventing inflammation with medication can lead to pain that is difficult to treat.

“For many decades, treating pain with anti-inflammatory medications has been standard medical practice. But we have found that this short-term fix can lead to long-term problems,” says Jeffrey Mogill, a professor in the McGill University Department of Psychology and chair of E. B. Taylor in Pain Studies.

The difference between people who get better and those who don’t

In the study published in Translational Medicine SciencesThe researchers examined pain mechanisms in both humans and mice. They found that neutrophils – a type of white blood cell that helps the body fight infection – play a key role in treating pain.

When analyzing the genes of people with low back pain, we observed active changes in the genes over time in people whose pain had disappeared. Changes in blood cell activity and activity seem to be the most important factor, particularly in cells called neutrophils,” says Luda Diachenko, MD, professor in the School of Medicine, College of Dentistry, and Canada Chair for Research Excellence in Human Pain Genetics.

Inflammation plays a major role in treating pain

Neutrophils dominate the early stages of inflammation and pave the way for tissue damage repair. Inflammation happens for a reason, and it seems dangerous to interfere with it,” says Professor Mogill, who is also a member of the Allan Edwards Center for Pain Research with Professor Dyachenko.

Experimental blocking of neutrophils in mice prolonged pain for up to ten times the normal duration. Treating pain with anti-inflammatory drugs and steroids such as dexamethasone and diclofenac produces the same result, although they were effective against pain early on.

these The findings are also supported by a separate analysis of 500,000 people in the UK that showed those taking anti-inflammatory drugs to treat their pain were more likely to develop pain two to ten years later, an effect not seen in people taking acetaminophen or anti-inflammatories. – Antidepressants.

Rethinking standard medical treatment for acute pain

Our findings suggest that it is time to reconsider the way we treat acute pain. “Fortunately, the pain can be eliminated by other methods that do not involve interfering with inflammation,” says Massimo Allegri, MD, a physician at the Policlinico of Monza Hospital in Italy and Ensemble Hospital de la Côte in Switzerland.

“We discovered that the resolution of pain is actually an active biological process,” says Professor Dyachenko. These findings should be followed up by clinical trials that directly compare anti-inflammatory drugs with other pain relievers that relieve aches and pains but do not disrupt inflammation.”

About this study

“Acute inflammatory response via neutrophil activation protects against development of chronic pain” by Mark Parisien et al. Posted in Translational Medicine Sciences.


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2022-05-12 00:06:47

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