Prediabetes in adulthood increases hospitalization risks associated with diabetes

Prediabetes in adulthood increases hospitalization risks associated with diabetes

Source / Disclosures


Jain A et al. Presentation 230. Presented at: American Heart Association Scientific Sessions on Quality of Care and Outcome Research. May 13-14, 2022; Reston, Virginia (Mixed meeting).

The authors do not report any relevant financial disclosures.

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Researchers report that young adults with prediabetes are nearly twice as likely to be hospitalized for myocardial infarction than young adults without impaired glucose tolerance, suggesting a need for more screening and awareness.

Achilles Jain

“After performing statistical testing and taking into account various influencing and adjusting factors, we found that young patients with prediabetes had 1.7 times higher chances of developing myocardial infarction compared with those without prediabetes,” Akhil Jain, MD, A resident physician at Mercy Catholic Medical Center in Darby, Pennsylvania, told Helio. “Although there were higher chances of developing myocardial infarction, prediabetes was not associated with a higher incidence of other significant adverse CV events, but required a higher proportion of patients being transferred to short-term facilities.”

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Jain and colleagues analyzed the incidence of MI-related hospitalizations among young adults aged 18–44 years with or without prediabetes, using the 2018 national inpatient sample. Adults with overt diabetes were excluded. The researchers evaluated comorbidities and outcomes, including major CV and cerebrovascular adverse events, based on prediabetes status.

The results were presented at the American Heart Association’s Scientific Sessions for Quality of Care and Outcomes Research.

The overall prevalence of prediabetes among young adults admitted to hospital in 2018 was 0.4%. MI-related hospitalizations were significantly higher among patients with prediabetes compared with those without prediabetes (2.15% versus 0.3%). Patients with prediabetes with MI-related hospital admissions were most often men (78.5% vs 72.8%), black (26.7% vs 21%), Hispanic (18.3% vs 11.5%) Asian/Ocean Islander Pacific (6.9% vs. 3.1%) or the highest-earning quartile (19.1% vs. 15.8%). In addition, patients with prediabetes were more likely to be treated in urban teaching hospitals (81.5% vs. 72.2%), than at Midwestern (23.7% vs. 21.9%) and Western (23% vs. 16.4%) hospitals compared with Those without prediabetes were more likely to have hyperlipidemia (68.1% vs 47.3%), obesity (48.9% vs 25.7%) and fluid-electrolyte imbalance (18.5% vs 15.3%).

After adjustment, patients with prediabetes were 71% more likely to be hospitalized for myocardial infarction compared with adults without prediabetes (odds ratio = 1.71; 9% confidence interval, 1.38–2.12; s .001).

However, subjects with prediabetes and hospitalizations associated with MI were no more likely to experience other adverse CV or cerebrovascular events than adults without prediabetes (q = .074).

“MI is a major life event that severely impacts the physical and mental health of a patient,” Jain told Helio. “The higher chances of developing MI among young people with prediabetes indicate the need to promote a healthy lifestyle in these people.”

Jain noted the paucity of large-scale epidemiological data on myocardial infarction among young adults, especially those with prediabetes.

“Our study should be considered as an early study to build future research based on the findings we proposed to clearly define the burden of heart disease in young people with prediabetes,” Jain told Helio. “It is essential to raise awareness among young people to follow up on routine health checks to screen for prediabetes in a timely manner and prevent the development of diabetes and associated CV events.”

2022-05-16 13:58:09

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